Scientists from Northwestern Medicine and the University of Belgrade have pinpointed the electrophysiological mechanism behind upper motor neuron (UMN) disease, unlocking the door to potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, such as Hereditary Spastic Paraplegia and Primary Lateral Sclerosis.
The study, published in Frontiers in Molecular Neuroscience on May 19, 2020, reveals the molecular underpinnings of electrical signals from potassium and sodium ion channels within the neuron’s cell membrane.
